Baicalin [21967-41-9]
Katalog-Nummer NB-64-16894-50mg
Size : 50mg
Marke : Neo Biotech
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Baicalin
(Synonyms: Baicalein 7-O-β-D-glucuronide) Copy Product InfoSynonyms: Baicalein 7-O-β-D-glucuronide
Catalog No. T2775 Copy Product Info
Purity: 99.32%
Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from Scutellaria baicalensis that exhibits anti-inflammatory, antioxidant, antitumor, and antiviral activity. Baicalin can be used in research on inflammation, neurodegenerative diseases, tumors, and metabolic syndrome.
Cas No. 21967-41-9
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.32%
Appearance:Solid
Color:White to Yellow
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Product Information
Baicalin AI Summary
Baicalin exhibits a diverse range of biological activities. It displays binding affinity to the benzodiazepine site in the GABAA receptor with a Ki value of 77624.71 nM and shows inhibitory activity against bovine testis hyaluronidase with various IC50 values ranging from 450,000.0 nM to 1,600,000.0 nM. It has antiviral activity against HIV1 3B in human H9 cells with an EC50 of 112000.0 nM and demonstrates cytotoxicity with an IC50 of 72000.0 nM. The compound also inhibits trypsin-induced elevation in PAI1 production in HUVEC cells with an IC50 greater than 1,000,000.0 nM and reduces concanavalin A-induced histamine release in Wistar rat peritoneal mast cells with an ID50 of 3.0 x 10^-6 M. Baicalin shows weak displacement of [3H]LSD from the human 5HT7 receptor with an IC50 above 200,000.0 nM, and activity against SARS-CoV-2 3CL-Pro protease by 50.66% at 20 µM. The compound has antibacterial, antifungal, and antiviral activities, including activity against Chikungunya virus and SARS-CoV-2 with varying efficacies. It shows hepatoprotective, anti-inflammatory, cytotoxic, and anti-proliferative properties in different model systems and cell lines. Additionally, Baicalin exhibits activity as an inhibitor of LSD1 with an IC50 of 3010.0 nM and antiproliferative activity against human MGC-803 cells with an IC50 of 8780.0 nM. It affects various biological processes, including cell cycle regulation, enzyme inhibition, and immunomodulation. The compound also has potential for modulating DNA interactions, particularly G4 quadruplex and i-motif structures, and demonstrates permeability across biological barriers..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from Scutellaria baicalensis that exhibits anti-inflammatory, antioxidant, antitumor, and antiviral activity. Baicalin can be used in research on inflammation, neurodegenerative diseases, tumors, and metabolic syndrome. |
| In vitro | Methods: RAW264.7 cells were treated with baicalin (12.5, 25, 50 μM) for 24 hours. Surface CD14 and TLR4 proteins were detected by flow cytometry, and CD14 mRNA was detected by RT-qPCR. Results: Baicalin dose-dependently inhibited CD14 protein and mRNA expression without affecting TLR4 expression. [1] |
| In vivo | Methods: C57BL/6 mice were established with ulcerative colitis (UC) by free access to a 3% DSS solution for 5 days. Following modeling, Baicalin (100 mg/kg) was administered orally via gavage once daily for 5 consecutive days. Results: Baicalin treatment restored colon length, reduced spleen index, alleviated ulcer severity, and significantly suppressed CD14 and IL-6 expression in colonic mucosa. [1] Methods: Adult male SD rats received continuous oral administration of Baicalin (20, 60, 120 mg/kg) once daily for two weeks prior to surgery. Following drug administration, the left anterior descending artery (LAD) was ligated for 45 minutes, followed by reperfusion for 180 minutes to establish an MI/RI model. Results: I/R significantly impaired cardiac function. Baicalin at 60 and 120 mg/kg significantly improved HR, LVSP, LVFS, and LVEF in a dose-dependent manner. [2] |
| Synonyms | Baicalein 7-O-β-D-glucuronide |
| Molecular Weight | 446.36 |
| Formula | C21H18O11 |
| Cas No. | 21967-41-9 |
| Smiles | OC1=C2C(OC(=CC2=O)C3=CC=CC=C3)=CC(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=C1O |
| Relative Density. | 1.737 g/cm3 |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 37 mg/mL (82.89 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.96 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||