Desmocollin 1 (DSC1) (NM_024421) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC214491L3V
- LentiORF®
Lenti ORF particles, DSC1 (Myc-DDK tagged) - Human desmocollin 1 (DSC1), transcript variant Dsc1a, 200ul, >10^7 TU/mL
ORF Plasmid: DDK tGFP
Lentiviral Particles: mGFP w/ Puro
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Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Desmocollin 1 |
Synonyms | CDHF1; DG2/DG3 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_024421 |
ORF Size | 2682 bp |
Sequence Data | The ORF insert of this clone is exactly the same as(RC214491). |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_024421.1, NP_077739.1 |
RefSeq Size | 4225 bp |
RefSeq ORF | 2685 bp |
Locus ID | 1823 |
UniProt ID | Q08554 |
Cytogenetics | 18q12.1 |
Protein Families | Transmembrane |
MW | 96.9 kDa |
Gene Summary | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015] |
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