Size : 1mg
Synonyms:
| Description | MitoTEMPO hydrate is a mitochondria-targeted antioxidant and superoxide scavenger. It mimics SOD activity to protect against mitochondrial oxidative stress in hypertension and neurodegeneration research. |
| In vitro | MitoTEMPO hydrate scavenges mitochondrial superoxide to inhibit mPTP opening, reducing necrosis and apoptosis in renal and endothelial cells [2][4]. |
| In vivo | In hypertensive mice, MitoTEMPO hydrate significantly lowers blood pressure and improves endothelium-dependent vasodilation by scavenging mitochondrial superoxide [3]. |
| Molecular Weight | 528.04 |
| Formula | C29H37ClN2O3P |
| Cas No. | 1569257-94-8 |
| Smiles | O=C(NC1CC(C)(C)N([O])C(C)(C)C1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-].O |
| Relative Density. | no data available |
| Storage | Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (9.47 mM), Sonication is recommmended. PBS (pH 7.2): < 1 mg/mL (insoluble), Sonication is recommended. Ethanol: 7.5 mg/mL (14.2 mM), Sonication is recommmended. DMF: 7.5 mg/mL (14.2 mM), Sonication is recommmended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/Ethanol/DMF
Ethanol/DMF
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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