Mouse Monoclonal Anti-MUC5AC (Mucin 5AC / Gastric Mucin) [Clone CLH2]
Katalog-Nummer NB-36-00535-P0
Size : 20ug
Marke : Neo Biotech
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MUC5AC (Mucin 5AC / Gastric Mucin) Antibody [CLH2]
Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Mouse Monoclonal Antibody (CLH2). Courtesy of Dr. Leonor David, IPATIMUP and Medical Faculty, University of Porto, Portugal.
SDS-PAGE Analysis of Purified MUC5AC Mouse Monoclonal Antibody (CLH2). Confirmation of Integrity and Purity of Antibody
Applications & Dilutions
Summary
Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric and tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas. The antibody recognizes the sequence TTSTTSAP within the tandem repeat of MUC5AC. It further recognizes glycosylated as well as unglycosylated MUC5AC.
Product Properties & Targets
Functions
- Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
Key References
- Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, et al. Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody. Int J Cancer 1997;74:112-
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/16554811/
- https://pubmed.ncbi.nlm.nih.gov/11535137/
- https://pubmed.ncbi.nlm.nih.gov/9506983/
- https://pubmed.ncbi.nlm.nih.gov/8948439/
- https://pubmed.ncbi.nlm.nih.gov/2656675/
- https://pubmed.ncbi.nlm.nih.gov/9620876/
- https://pubmed.ncbi.nlm.nih.gov/7513696/
- https://pubmed.ncbi.nlm.nih.gov/7775418/
- https://pubmed.ncbi.nlm.nih.gov/16787389/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/17974005/
- https://pubmed.ncbi.nlm.nih.gov/11445551/
- https://pubmed.ncbi.nlm.nih.gov/14535999/
- https://pubmed.ncbi.nlm.nih.gov/14718370/
- https://pubmed.ncbi.nlm.nih.gov/22186971/
- https://pubmed.ncbi.nlm.nih.gov/25939779/
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