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> Notch 2 Protein, Human, Recombinant (His & Avi)

Notch 2 Protein, Human, Recombinant (His & Avi)

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Katalog-Nummer NB-64-54208-50ug

Size : 50ug

Marke : Neo Biotech


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Notch 2 Protein, Human, Recombinant (His & Avi)

(Synonyms: Notch-2, NOTCH2, N2ECD, N2, HJCYS, AGS2) Copy Product Info

Synonyms: Notch-2, NOTCH2, N2ECD, N2, HJCYS, AGS2

Catalog No. TMPK-00465 Copy Product Info
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Other Forms of Notch 2 Protein, Human, Recombinant (His & Avi):
Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated
N-2 Supplement (100X), Serum-free
Notch 2 Protein, Human, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Species
Human
Expression System
HEK293 Cells
TagC-His-Avi
Accession NumberQ04721
ConstructionLeu26-GIn530
Protein Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationSupplied as 0.22 μm filtered solution in PBS (pH 7.4).
SynonymsNotch-2, NOTCH2, N2ECD, N2, HJCYS, AGS2
Research Background
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Chemical Properties
Molecular Weight57 kDa (predicted). Due to glycosylation, the protein migrates to 68-78 kDa based on Tris-Bis PAGE result.
Storage & Solubility Information
ShippingProteins are shipped with blue ice.
StorageIt is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

NOTCH 2N-2N 2AGS-2AGS 2
Related Tags: Notch 2 Protein, Human, Recombinant (His & Avi) chemical structure | Notch 2 Protein, Human, Recombinant (His & Avi) molecular weight