Recombinant HCMV Envelope Glycoprotein B (Postfusion)
Katalog-Nummer DRA263-50ug
Size : 50ug
Marke : Novoprotein
Description Recombinant HCMV (strain AD169) Envelope Glycoprotein B is produced by our Mammalian expression system and the target gene encoding Ser25-Pro706 is expressed with a 6His tag at C-terminus.Y155G, I156H, Y157R, Y206H, W240A, L241T, Y242H and RTRR456-459GSAS mutations are introduced to stabilize the trimeric postfusion state of Glycoprotein B and abolish the furin cleavage site, respectively.
Accession P06473
Known As Envelope glycoprotein B; gB; UL55
Mol Mass 78.4 kDa
APMol Mass 100-155 kDa, reducing conditions
Formulation Description Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Purity-SDS-PAGE 
Greater than 95% as determined by reducing SDS-PAGE. (QC verified) Storage - Reconstituted protein solution should be stored at ≤ -20°C.
- Stable for at least 24 months when stored as instructed.
Shipping The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background Human cytomegalovirus (HCMV) is the most common virus transmitted in utero and is also an important cause of disease in adults. Both the congenital transmission of HCMV and its ability to cause disease in adulthood, particularly in immunosuppressed patients, pose important challenges in clinical practice. Glycoprotein B (gB) is one of several glycoproteins expressed in the viral envelope that mediate viral entry into cells, gB works in concert with the gH/gL complex to facilitate viral entry into human fibroblasts, and with the PC to enter epithelial and endothelial cells. The glycoprotein is highly conserved among herpesviruses and its expression is essential for HCMV replication.