Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. [[654671-78-0]]
Katalog-Nummer orb1910069-100mg
Size : 100mg
Marke : Biorbyt
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Sitagliptin phosphate
Catalog Number: orb1910069
| Catalog Number | orb1910069 |
|---|---|
| Category | Small Molecules |
| Description | Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. |
| CAS Number | [654671-78-0] |
| MW | 505.3088 |
| SMILES | P(=O)(O03)(O03)O03.FC(C1=NN=C2C(03)(03)N(C(C(03)(03)[C@@](03)(C(03)(03)C3=C(03)C(=C(C(03)=C3F)F)F)N(03)03)=O)C(03)(03)C(03)(03)N21)(F)F |
| Formula | C16H18F6N5O5P |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |