LMP744 hydrochloride [308246-57-3]
Cat# T11872L-1mg
Size : 1mg
Brand : TargetMol
LMP744 hydrochloride
(Synonyms: NSC706744 hydrochloride, MJ-III65 hydrochloride) Copy Product Info
LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
Cas No. 308246-57-3
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.85%
Appearance:Solid
Color:Yellow
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
| In vitro | LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2]. |
| In vivo | LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1]. |
| Synonyms | NSC706744 hydrochloride, MJ-III65 hydrochloride |
| Molecular Weight | 488.92 |
| Formula | C24H25ClN2O7 |
| Cas No. | 308246-57-3 |
| Smiles | Cl.COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC |
| Relative Density. | no data available |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.56 mg/mL (11.37 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||