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> NRG1 alpha Protein, Human, Recombinant (hFc)

NRG1 alpha Protein, Human, Recombinant (hFc)

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Cat# NB-64-57816-1mg

Size : 1mg

Brand : Neo Biotech


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NRG1 alpha Protein, Human, Recombinant (hFc)

(Synonyms: SMDF, NRG1-IT2, NRG1 α, Neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA) Copy Product Info

Synonyms: SMDF, NRG1-IT2, NRG1 α, Neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA

Catalog No. TMPY-02720 Copy Product Info
NRG1 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 51 kDa and the accession number is Q02297-1.
Other Forms of NRG1 alpha Protein, Human, Recombinant (hFc):
NRG1 beta 1 Protein, Human, Recombinant (E. coli)
ECSCR Protein, Human, Recombinant (hFc)
ECSCR Protein, Mouse, Recombinant (hFc)
Neuregulin-1/NRG1 Protein, Human, Recombinant (His)
Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)
NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)
NRG1 beta 1 Protein, Human, Recombinant (hFc)
NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc)
NRG1 alpha Protein, Human, Recombinant (His)
NRG1 beta 1 Protein, Human, Recombinant
Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc)
Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 19-240, His)
Neuregulin-1/NRG1 Protein, Canine, Recombinant (hFc)
LIPF Protein, Human, Recombinant (His)
Neuregulin-1/NRG1 Protein, Canine, Recombinant
Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Bioactivity
1. Measured by its ability to biotinylated Human ErbB4-Fc in functional Elisa. 2. Measured by its ability to biotinylated Rhesus ErbB3-His in functional Elisa. 3. Measured by its ability to biotinylated Rhesus ErbB3 in functional Elisa.
Description
NRG1 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 51 kDa and the accession number is Q02297-1.
Species
Human
Expression System
HEK293 Cells
TagC-hFc
Accession NumberQ02297-1
ConstructionA DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) extracellular domain (Ser 20-Lys 241) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ser 20
Protein Purity
> 87 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsSMDF, NRG1-IT2, NRG1 α, Neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA
Research Background
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
Chemical Properties
Molecular Weight51 kDa (predicted); 60 kDa (reducing conditions)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

MSTP-131MSTP 131MST-131MST 131HRG-1HRG 1GGF-2GGF 2
Related Tags: NRG1 alpha Protein, Human, Recombinant (hFc) chemical structure | NRG1 alpha Protein, Human, Recombinant (hFc) molecular weight