Reagents and instruments for immunology, cell biology and molecular biology.

Paclobutrazol [76738-62-0]

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Cat# T38273-1g

Size : 1g

Brand : TargetMol

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Paclobutrazol (Synonyms: 2R,3R-Paclobutrazol, (R,R)-paclobutrazol, (2R,3R)-Paclobutrazol)

Paclobutrazol

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Synonyms 2R,3R-Paclobutrazol, (R,R)-paclobutrazol, (2R,3R)-Paclobutrazol

Cas No. 76738-62-0

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.23%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Paclobutrazol AI Summary

Paclobutrazol exhibits bioactivities related to various nuclear receptors and signaling pathways. It acts as an agonist for retinoid X receptor alpha, glucocorticoid receptor, peroxisome proliferator-activated receptor delta, antioxidant response element, rat pregnane X receptor (rPXR), and human pregnane X receptor (PXR) signaling pathways, with varying potencies in the nanomolar range. Additionally, it also functions as an antagonist for peroxisome proliferator-activated receptor delta signaling..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Paclobutrazol ((R,R)-paclobutrazol) is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.1,2It also has antifungal activities.3PBZ, which is transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants.1,4,5PBZ is typically used to support research on the role of gibberellins in plant biology.

Synonyms

2R,3R-Paclobutrazol, (R,R)-paclobutrazol, (2R,3R)-Paclobutrazol

Chemical Properties

Molecular Weight	293.79
Formula	C₁₅H₂₀ClN₃O
Cas No.	76738-62-0
Smiles	CC(C)(C)[C@@H](O)[C@@H](Cc1ccc(Cl)cc1)n1cncn1
Relative Density.	1.22 g/cm3

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 10 mg/mL (34.04 mM), Sonication is recommended.

DMSO: 105 mg/mL (357.4 mM), Sonication is recommended.

Ethanol: 10 mg/mL (34.04 mM), Sonication is recommended.

Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL (1.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.6808 mL	3.4038 mL	6.8076 mL	34.0379 mL
10 mM	0.3404 mL	1.7019 mL	3.4038 mL	17.0190 mL
20 mM	0.1702 mL	0.8509 mL	1.7019 mL	8.5095 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.