CD45 / LCA Rat Monoclonal Antibody [Clone ID: EM-05]

CAT#: AM26024AC-N

CD45 / LCA rat monoclonal antibody, clone EM-05, APC

Conjugation: Unconjugated APC PE


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Specifications

Product Data
Clone Name EM-05
Applications FC
Recommended Dilution Flow Cytometry: Use at 4 µg/ml.
Reactivities Mouse
Host Rat
Isotype IgG
Clonality Monoclonal
Immunogen Murine peripheral blood leukocytes
Specificity The antibody EM-05 reacts with Mouse CD45 antigen (Leukocyte Common Antigen), a single chain type I transmembrane protein expressed at high level on cells of hematopoietic origin, except erythrocytes and platelets.
Formulation PBS
Label: APC
State: Liquid purified Ig fraction
Preservative: 15mM Sodium Azide
Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions
Concentration lot specific
Purification Size-Exclusion Chromatography
Conjugation APC
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
This products is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name protein tyrosine phosphatase, receptor type, C
Background CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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