Human Phosphatidic acid phosphatase type 2B (PLPP3) activation kit by CRISPRa

CAT#: GA105702

PLPP3 CRISPRa kit - CRISPR gene activation of human phospholipid phosphatase 3



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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol PLPP3
Locus ID 8613
Kit Components

GA105702G1, Phosphatidic acid phosphatase type 2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105702G2, Phosphatidic acid phosphatase type 2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105702G3, Phosphatidic acid phosphatase type 2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_003713, NM_177414
UniProt ID O14495
Synonyms Dri42; LPP3; PAP2B; PPAP2B; VCIP
Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

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