Mouse Hdac2 activation kit by CRISPRa
CAT#: GA201861
Hdac2 CRISPRa kit - CRISPR gene activation of mouse histone deacetylase 2
Find the corresponding CRISPRi Inhibitor Kit
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Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
| Symbol | Hdac2 |
| Locus ID | 15182 |
| Kit Components | GA201861G1, Hdac2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201861G2, Hdac2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201861G3, Hdac2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_008229 |
| UniProt ID | P70288 |
| Synonyms | D10Wsu179e; mRPD3; YAF1; Yy1bp |
| Summary | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN307617 | Hdac2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN307617BN | Hdac2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN307617LP | Hdac2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN307617RB | Hdac2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN507617 | Hdac2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR |