Mouse Hdac9 activation kit by CRISPRa

CAT#: GA211088

Hdac9 CRISPRa kit - CRISPR gene activation of mouse histone deacetylase 9



Find the corresponding CRISPRi Inhibitor Kit

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Hdac9
Locus ID 79221
Kit Components

GA211088G1, Hdac9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA211088G2, Hdac9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA211088G3, Hdac9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001271386, NM_024124
UniProt ID Q99N13
Synonyms AV022454; D030072B18Rik; HD7B; HD9; Hdac7b; HDRP; Mitr; mKIAA0744
Summary Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.[UniProtKB/Swiss-Prot Function]

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