Human Inosine triphosphate pyrophosphatase (ITPA) activation kit by CRISPRa

CAT#: GA102492

ITPA CRISPRa kit - CRISPR gene activation of human inosine triphosphatase



Find the corresponding CRISPRi Inhibitor Kit

Product Images

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol ITPA
Locus ID 3704
Kit Components

GA102492G1, Inosine triphosphate pyrophosphatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102492G2, Inosine triphosphate pyrophosphatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102492G3, Inosine triphosphate pyrophosphatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001267623, NM_033453, NM_181493, NR_052000, NR_052001, NR_052002, NM_001324236, NM_001324237, NM_001324238, NM_001324240, NM_001351739
UniProt ID Q9BY32
Synonyms C20orf37; dJ794I6.3; HLC14-06-P; My049
Summary This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Documents

Other Versions