Mitofusin 2 antibody

Cat# orb150804-100ug

Size : 100ug

Brand : Biorbyt

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Mitofusin 2 antibody

Mitofusin 2 antibody

Catalog Number: orb150804

Catalog Numberorb150804
CategoryAntibodies
DescriptionMouse monoclonal to Mitofusin 2 (ATTO-488). Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression..
Species/HostMouse
ClonalityMonoclonal
Clone NumberS153-5
Tested applicationsICC, IHC, WB
ReactivityHuman, Mouse, Rat
IsotypeIgG2a
ImmunogenFusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
Concentration1 mg/ml
Dilution rangeWB (1:1000), ICC/IF (1:100)
ConjugationATTO-488
MW90kDa
TargetMitofusin 2
Entrez170731
UniProt IDQ80U63
NCBINP_573464.2
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Alternative namesCMT2A antibody, CMT2A2 antibody, CPRP 1 antibody,
NoteFor research use only
Application notes1 µg/ml of SMC-457 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Expiration Date12 months from date of receipt.