General Information
| Short Description | Mouse monoclonal anti-Synaptonemal complex protein 3 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:1000-1:2000 |
| Formulation | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen | Purified recombinant human SCP-3 protein fragments expressed in E.coli. |
| Specificity | SCP-3 Monoclonal Antibody detects endogenous levels of SCP-3 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. |
| Protein Name | Synaptonemal Complex Protein 3Scp-3 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCentromereIt Is Present In Early Unpaired CoresIn The Lateral Domains Of The Synaptonemal Complex And In The Chromosome Cores When They Separate At DiploteneIt Is Found Axial To The Metaphase I Chromosomes And In Association With Pairs Of Sister CentromeresThe Centromere-Associated Protein Becomes Dissociated From The Centromeres At Anaphase Ii And Is Not Found In Mitotic Metaphase Centromeres |
| Alternative Antibody Names | Anti-Synaptonemal Complex Protein 3 antibodyAnti-Scp-3 antibodyAnti-SYCP3 antibodyAnti-SCP3 antibody |
Information sourced from Uniprot.org