TICAM1 Recombinant Protein

Cat# OPCD07436-200UG

Size : 200ug

Brand : Aviva Systems Biology

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Datasheets/ManualsPrintable datasheet for TICAM1 Recombinant Protein (OPCD07436)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ser263-Val526
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 97%
SourceE.coli
TagN-terminal His Tag
Gene SymbolTicam1
Gene Full Nametoll-like receptor adaptor molecule 1
Alias SymbolsAW046014;AW547018;TICAM;TICAM-1;TIR domain-containing adapter molecule 1;TIR domain-containing adapter protein inducing IFN-beta;TIR domain-containing adaptor inducing interferon-beta;toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;Tr;TRIF.
NCBI Gene Id106759
Protein NameTIR domain-containing adapter molecule 1
Description of TargetInvolved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Uniprot IDQ80UF7
Protein Accession #NP_778154.1
Nucleotide Accession #NM_174989.4
Protein Size (# AA)Ser263~Val526
Molecular Weight39kDa