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Diacylglycerols

Diacylglycerols

Diacylglycerols (DAGs), also known as diglycerides, are neutral glycerolipids consisting of a glycerol backbone esterified with two fatty acyl chains, typically at the sn-1 and sn-2 positions. These versatile lipids serve as key metabolic intermediates, intracellular second messengers, and structural components involved in membrane organization and cellular signaling pathways.

Chemical Structure

DAG molecules are composed of a central glycerol moiety bearing two hydrophobic fatty acid chains that may vary in length, degree of saturation, and stereochemical position. This structural diversity generates numerous molecular species, such as 1-stearoyl-2-arachidonoyl-sn-glycerol, commonly produced during phospholipase C–mediated hydrolysis of phosphatidylinositol phosphates. Three regioisomeric forms exist (1,2-, 1,3-, and 2,3-DAG), with 1,2-sn-DAG predominating in biological systems due to enzymatic stereospecificity. The sn-2 acyl chain often adopts a bent conformation, initially oriented parallel to the lipid bilayer before aligning with the sn-1 chain.

Physical Properties

In the pure state, DAGs exhibit polymorphic behavior, including β′ crystalline phases (stable monoclinic structures with tilted hydrocarbon chains), lamellar arrangements, and fluid phases. Owing to their small polar headgroup relative to their acyl chains, DAGs favor negative membrane curvature. When incorporated into phospholipid bilayers, they tend to segregate into DAG-enriched microdomains, induce dehydration of neighboring phospholipid headgroups, and localize approximately two methylene units deeper within the membrane core compared with surrounding lipids. These properties facilitate membrane fusion events and the formation of non-lamellar lipid phases.

Biosynthesis and Metabolism

DAGs are generated primarily through two major pathways: dephosphorylation of phosphatidic acid in the Kennedy pathway, and phospholipase C–mediated hydrolysis of membrane phospholipids. These reactions link DAG metabolism to the biosynthesis of triacylglycerols, phosphatidylcholine, and phosphatidylethanolamine. Lipin family phosphatidic acid phosphatases and diacylglycerol acyltransferase (DGAT) enzymes regulate the interconversion between phosphatidic acid, DAG, and triacylglycerols. Regioisomer composition is further refined through acyl chain remodeling catalyzed by lipases and acyltransferases.

 


Frequently Asked Questions (FAQ)

Where can I find diacylglycerols products on the CliniSciences website?

diacylglycerols products are available in this section and can be sorted by product families or sub-categories, such as Dioleoylglycerol, Dipalmitoylglycerol, Dilinoleoylglycerol. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the diacylglycerols category?

The diacylglycerols category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The Dilinoleoylglycerol, Dipalmitoylglycerol, Dioleoylglycerol sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a diacylglycerols product?

To find a diacylglycerols product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does CliniSciences stock several product codes in the diacylglycerols category?

Yes, CliniSciences distributes several product references in the diacylglycerols category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for diacylglycerols products?

Yes, you can request a quote for diacylglycerols products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a diacylglycerols product is available to order?

The availability of a diacylglycerols product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.

What should I do if I cannot find the diacylglycerols product I am looking for?

If the diacylglycerols product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all diacylglycerols products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.