Tetramers and monomers
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. While it was believed that antigen-specific T cells could be detected using soluble MHC/peptide complexes, monomeric MHC/peptide complexes proved to be impractical due to their instability and low affinity yo TCRs. To overcome this difficulty, MHC/peptide monomers are biotinylated and tetramerized with streptavidin to maintain stable binding to multiple TCRs, enabling MHC/peptide tetramers to be used as detection tools. MHC tetramers are labeled with fluorescent molecules such as phycoerythrin (PE), allophycocyanin (APC) or Brilliant Violet 421 (BV421) and thus allow detection of antigen specific T cells by flow cytometry or fluorescence microscopy.
- Tetramers offer Superior Specificity with α3 Mutation
- Class I and Class II Available
- PE, APC and BV421 Conjugates Available
- Over 60 alleles available
- Custom Services Available
Frequently Asked Questions (FAQ)
Where can I find tetramers and monomers products on the CliniSciences website?
What types of products are available in the tetramers and monomers category?
How can I quickly find a tetramers and monomers product?
To find a tetramers and monomers product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.
Does CliniSciences stock several product codes in the tetramers and monomers category?
Yes, CliniSciences distributes several product references in the tetramers and monomers category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.
Can I request a quote for tetramers and monomers products?
Yes, you can request a quote for tetramers and monomers products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.
How can I find out if a tetramers and monomers product is available to order?
The availability of a tetramers and monomers product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.
What should I do if I cannot find the tetramers and monomers product I am looking for?
If the tetramers and monomers product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.
Are all tetramers and monomers products available under the same terms and conditions?
No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.