GSK3 beta (GSK3B) Mouse Monoclonal Antibody [Clone ID: 3A11]

CAT#: AM08187HR-N

GSK3 beta (GSK3B) mouse monoclonal antibody, clone 3A11, HRP

Conjugation: Unconjugated HRP


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Specifications

Product Data
Clone Name 3A11
Applications ELISA, WB
Recommended Dilution ELISA: 1/1,000-1/2,000.
Western Blot.
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody is specific for GSK3 beta.
Formulation 50% Glycerol/50% PBS, pH 7.4 without preservatives.
Label: HRP
State: Liquid purified Ig fraction.
Label: Horseradish Peroxidase
Conjugation HRP
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Synonyms GSK-3 beta, Glycogen synthase kinase-3 beta, GSK3B
Reference Data

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