Reagents and instruments for immunology, cell biology and molecular biology.

α-Terpineol [98-55-5]

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Cat# Fr14115-10g

Size : 10g

Brand : TargetMol

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α-Terpineol (Synonyms: Terpineol)

α-Terpineol

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Synonyms Terpineol

Cas No. 98-55-5

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:97.02%

Appearance:solid

Color:White

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COA LCMS HNMR GC

Product Introduction

α-Terpineol AI Summary

α-Terpineol displays a diverse range of bioactivities across various assays. It functions as a potent modulator of Lamin A splicing with a potency of 3.5 nM and inhibits Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 89125.1 nM. Additionally, it inhibits the binding or entry of Marburg Virus into cells with a potency of 2238.7 nM. In anti-asthmatic applications, α-Terpineol reduces acetylcholine-induced muscle contractions and promotes muscle relaxation in guinea pig tracheal smooth muscle rings. It improves lung function in ovalbumin-induced asthmatic Sprague-Dawley rats by decreasing serum IL-17 and IL-14 levels and enhancing airway compliance. Moreover, it acts as an agonist at the beta-adrenergic receptor in rat airway smooth muscle cells, increasing cAMP levels post-acetylcholine stimulation. In neurological studies, α-Terpineol serves as a positive allosteric modulator of the recombinant human GABAA alpha1beta2gamma2s receptor, achieving a GABA-stimulated current amplitude of 91.2% of the control in Xenopus laevis oocytes. It has a sedative effect in Swiss mice, reducing motility by 45.0% at a concentration of 34 nM. Antimicrobial activities were observed against Candida albicans (MIC of 0.125% v/v), Gardnerella vaginalis (MIC of 0.06% v/v), and Escherichia coli CMCC 44102 (MIC of 0.78 uL/ml). Additionally, it inhibits ARAT and LRAT enzymes in bovine RPE microsomes, with inhibition rates of 26.0% and 25.0% respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.
Synonyms	Terpineol

Chemical Properties

Molecular Weight	154.25
Formula	C₁₀H₁₈O
Cas No.	98-55-5
Smiles	C(C)(C)(O)C1CCC(C)=CC1
Relative Density.	0.93 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (291.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (32.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4830 mL	32.4149 mL	64.8298 mL	324.1491 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL	64.8298 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	6.4830 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.