Adenosine 5'-diphosphate [58-64-0]
Cat# T1723-100mg
Size : 100mg
Brand : TargetMol
Adenosine 5'-diphosphate (Synonyms: ADP, adenosine pyrophosphate, Adenosine diphosphate)
Adenosine 5'-diphosphate
Copy Product InfoSynonyms ADP, adenosine pyrophosphate, Adenosine diphosphate
Cas No. 58-64-0
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.81%
Color:White
Product Introduction
Adenosine 5'-diphosphate AI Summary
Adenosine 5'-diphosphate exhibits a diverse range of bioactivities based on various assays. It acts as an agonist at the phospholipase C-coupled P2Y1 purinoceptor in turkey erythrocytes (EC50 = 8000 nM) and demonstrates antagonist activity against phospholipase C-coupled rat P2Y12 purinoceptor (EC50 = 69.0 nM) and recombinant human P2X1 purinoceptor (EC50 = 10,000 nM). It also shows varying antagonistic activities against several P2X purinoceptor subtypes (P2X2, P2X3, P2X4, P2X5, P2X6) with EC50 values between 11,000 and 28,000 nM. Additionally, Adenosine 5'-diphosphate is shown to inhibit ribonucleotide reductase (Km = 34,000 nM) and Nucleoside Triphosphate Diphosphohydrolase (Km = 33,000 nM). Furthermore, it has different affinities for binding HSP70 (IC50 and Kd = 500 nM), shows inhibition of various kinases such as human phosphatidylinositol 4-kinase (IC50 = 145,300 nM and Ki = 100,100 nM), and demonstrates modulation of pyruvate kinase activities in rat tissues with Km values ranging from 300,000 to 520,000 nM. The compound also affects platelet shape change and aggregation, shows moderate bioactivity in inhibiting binding or entry into cells for viruses such as SARS-CoV-2, and displays potential neuroprotective and antioxidant activities. Overall, Adenosine 5'-diphosphate demonstrates multifunctional properties that make it a candidate of interest for further pharmacological studies..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Adenosine 5'-diphosphate (ADP) is a naturally occurring nucleotide derived from the dephosphorylation of ATP. Adenosine 5'-diphosphate is essential for cellular metabolism and induces platelet aggregation. |
| Targets&IC50 | P2X2/3:67 nM, P2Y1:24 nM (EC50) |
| In vitro | METHODS: Fibroblast-like synoviocytes FLS1 were treated with Adenosine 5'-diphosphate (100 µM) for 24 h, and gene expression levels were measured by RT-qPCR. RESULTS: MCP-1/CCL-2 mRNA expression was up-regulated 2.31-fold in FLS1 cells treated with Adenosine 5'-diphosphate (100 µM). [1] |
| In vivo | METHODS: To investigate the role in tissue repair, Adenosine 5'-diphosphate (15.2 µg/kg) was applied topically to diabetic mice in a total excisional wound model once daily for 14 days. RESULTS: Adenosine 5'-diphosphate accelerated cutaneous wound healing, improved new tissue formation, and increased collagen deposition and TGF-β production in the wounds.Adenosine 5'-diphosphate acts as a pro-absorptive mediator in diabetes-related cutaneous wounds. [2] |
| Synonyms | ADP, adenosine pyrophosphate, Adenosine diphosphate |
| Molecular Weight | 427.2 |
| Formula | C10H15N5O10P2 |
| Cas No. | 58-64-0 |
| Smiles | O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O |
| Relative Density. | 2.49 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (234.08 mM), Sonication is recommended.  DMSO: 14 mM, Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||