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Anti-AGT Monoclonal Antibody

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Cat# NB-64-126578-50ug

Size : 50ug

Brand : Neo Biotech


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Anti-AGT Monoclonal Antibody

(Synonyms: Serpin A8, Angiotensinogen) Copy Product Info

Synonyms: Serpin A8, Angiotensinogen

Catalog No. TMAZ-0159 Copy Product Info
Anti-AGT Monoclonal Antibody is a humanized rabbit antibody targeting AGT. Anti-AGT Monoclonal Antibody can be used in FCM.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Description
Anti-AGT Monoclonal Antibody is a humanized rabbit antibody targeting AGT. Anti-AGT Monoclonal Antibody can be used in FCM.
SynonymsSerpin A8, Angiotensinogen
Ig Type
Rabbit monoclonal IgG
Reactivity
Human
Verified Activity
Flow cytometry analysis of AGT overexpressed 435F cells with TMAZ-0159, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
Application
FCM
Recommended Dose
0.1-0.2 μg/10^6 cells for FCM
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted
ConstructionThis antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AGT protein.
PurificationProtein A Affinity Purified
AppearanceLiquid
Formulation0.22 μm filtered solution in PBS.
Purity> 95% as determined by SDS-PAGE.
Research BackgroundEssential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis|Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed: 10619573, PubMed: 17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed: 1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity)|Stimulates aldosterone release|Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity)
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Biotin
Antibody Types Available
2
Antigen Details
Immunogen
AGT
Antigen Species
Human
Gene ID
183
Uniprot ID
P01019
Biology Area
Drug Target
Chemical Properties
Molecular Weight150 kDa
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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