Anti-Atypical Chemokine Receptor D6 antibody (300-378) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Ackr2
Gene ID:	59289
Uniprot ID:	ACKR2_MOUSE
Immunogen Region:	300-378
Immunogen:	Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein.

Tissue Specificity	Expressed on apoptotic neutrophils (at protein level).
Post Translational Modifications	Phosphorylated on serine residues in the C-terminal cytoplasmic tail.
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Protein Name	Atypical Chemokine Receptor 2 C-C Chemokine Receptor D6 Chemokine-Binding Protein 2 Chemokine-Binding Protein D6
Database Links	Reactome: R-MMU-380108
Cellular Localisation	Early Endosome Recycling Endosome Cell Membrane Multi-Pass Membrane Protein Predominantly Localizes To Endocytic Vesicles And Upon Stimulation By The Ligand Is Internalized Via Clathrin-Coated Pits Once Internalized The Ligand Dissociates From The Receptor And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Antibody Names	Anti-Atypical Chemokine Receptor 2 antibody Anti-C-C Chemokine Receptor D6 antibody Anti-Chemokine-Binding Protein 2 antibody Anti-Chemokine-Binding Protein D6 antibody Anti-Ackr2 antibody Anti-Ccbp2 antibody Anti-D6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance