Anti-CD106/Vcam1 antibody [M/K-2.7] {AF647}

Clonality:	Monoclonal
Clone ID:	M/K-2.7
Conjugation:	AF647
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Concentration:	0.5 mg/mL
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:

Vcam1Uniprot ID=VCAM1_MOUSE"

Tissue Specificity	Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
Post Translational Modifications	Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation.
Function	Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
Protein Name	Vascular Cell Adhesion Protein 1 V-Cam 1 Vcam-1 Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1
Cellular Localisation	Vascular Cell Adhesion Protein 1: Cell Membrane Single-Pass Type I Membrane Protein Soluble Vascular Cell Adhesion Molecule-1: Secreted
Alternative Antibody Names	Anti-Vascular Cell Adhesion Protein 1 antibody Anti-V-Cam 1 antibody Anti-Vcam-1 antibody Anti-Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 antibody Anti-Vcam1 antibody Anti-Vcam-1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance