Anti-MeCP2 isoform 1 antibody (1-50) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	MECP2
Gene ID:	4204
Uniprot ID:	MECP2_HUMAN
Immunogen Region:	1-50
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1.

Tissue Specificity	Present in all adult somatic tissues tested.
Post Translational Modifications	Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.
Function	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Protein Name	Methyl-Cpg-Binding Protein 2 Mecp-2 Protein Mecp2
Database Links	Reactome: R-HSA-8986944 Reactome: R-HSA-9022534 Reactome: R-HSA-9022535 Reactome: R-HSA-9022537 Reactome: R-HSA-9022538 Reactome: R-HSA-9022692 Reactome: R-HSA-9022699 Reactome: R-HSA-9022702 Reactome: R-HSA-9022707 Reactome: R-HSA-9022927 Reactome: R-HSA-9725371
Cellular Localisation	Nucleus Colocalized With Methyl-Cpg In The Genome Colocalized With Tbl1x To The Heterochromatin Foci
Alternative Antibody Names	Anti-Methyl-Cpg-Binding Protein 2 antibody Anti-Mecp-2 Protein antibody Anti-Mecp2 antibody Anti-MECP2 antibody

Information sourced from Uniprot.org

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