Gentamicin sulfate, 100X solution [1405-41-0]
Cat# sc-361877
Size : 10ml
Brand : Santa Cruz Biotechnology
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Gentamicin sulfate, 100X solution (CAS 1405-41-0)
Noms alternatifs:
Gentimicin Sulfate solution; Garamycin solution; Gentiomycin C solution
Application:
Gentamicin sulfate, 100X solution is a product which acts by inhibiting protein synthesis in susceptible bacteria
Numéro CAS:
1405-41-0
Masse Moléculaire:
575.67
Formule Moléculaire:
C21H43N5O7•H2SO4
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).
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Description
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SDS & Certificat d’Analyses
Gentamicin sulfate is a powerful broad-spectrum antibiotic that exhibits minimal toxicity to viruses and mammalian cells even at antibacterial concentrations. It effectively inhibits the growth of both gram-positive and gram-negative bacteria, as well as mycoplasma. This antibiotic exerts its action by binding to the L6 protein of the 50S ribosomal subunit, thereby impeding normal protein synthesis. Notably, it is particularly valuable in Baculovirus expression systems due to its ability to overcome mutations in rplF that render other antibiotics ineffective. Comprised of various gentamicin components, gentamicin sulfate is classified as an aminoglycoside antibiotic. The primary constituents, namely gentamicin C1, gentamicin C1a, and gentamicin C2, make up approximately 80% of gentamicin and exhibit the highest antibacterial potency. The remaining 20% is comprised of gentamicin A, B, X, and a few others, which possess comparatively lower antibiotic activity when compared to the gentamicin C complex. Gentamicin displays a slight solubility in aqueous solutions, with a concentration of approximately 12.6 mg/mL.
References:
- Investigation of the in vitro release of gentamicin from a polyanhydride matrix. | Stephens, D., et al. 2000. J Control Release. 63: 305-17. PMID: 10601726
- Elution of metronidazole and gentamicin from polymethylmethacrylate beads. | Ramos, JR., et al. 2003. Vet Surg. 32: 251-61. PMID: 12784202
- A controlled and sustained local gentamicin delivery system for inner ear applications. | Xu, L., et al. 2010. Otol Neurotol. 31: 1115-21. PMID: 20616758
- A new type of biphasic calcium phosphate cement as a gentamicin carrier for osteomyelitis. | Su, WY., et al. 2013. Evid Based Complement Alternat Med. 2013: 801374. PMID: 23662153
- Intratympanic gentamicin as a treatment for drop attacks in patients with Meniere′s disease. | Viana, LM., et al. 2014. Laryngoscope. 124: 2151-4. PMID: 24729095
- Electrophoretic deposition of gentamicin-loaded bioactive glass/chitosan composite coatings for orthopaedic implants. | Pishbin, F., et al. 2014. ACS Appl Mater Interfaces. 6: 8796-806. PMID: 24827466
- Chemical injury of the spinal cord of the rabbit after intracisternal injection of gentamicin. | Watanabe, I., et al. 1979. J Neuropathol Exp Neurol. 38: 104-13. PMID: 261984
- Sensory hair fusion and glycocalyx changes after gentamicin exposure in the guinea pig. | Takumida, M., et al. 1989. Acta Otolaryngol Suppl. 457: 78-82. PMID: 2929338
- Collagen-shield delivery of gentamicin and vancomycin. | Phinney, RB., et al. 1988. Arch Ophthalmol. 106: 1599-604. PMID: 3190546
- An IgG, gentamicin sulfate-dependent antibody found during prenatal antibody screening. | Peloquin, PM., et al. 1986. Vox Sang. 51: 321-3. PMID: 3798866
- A clinical comparison of tobramycin and gentamicin sulfate in the treatment of ocular infections. | Laibson, P., et al. 1981. Am J Ophthalmol. 92: 836-41. PMID: 7032304
- Damage and recovery of hair cells in fish canal (but not superficial) neuromasts after gentamicin exposure. | Song, J., et al. 1995. Hear Res. 91: 63-71. PMID: 8647725
- Stability of gentamicin sulfate injection following unit dose repackaging. | Weiner, B., et al. 1976. Am J Hosp Pharm. 33: 1254-9. PMID: 998642
Utilisation :
Recommended working concentration: 100 µg/ml
Formulation :
10 mg/ml in DI water
État Physique :
Liquid
STOCKAGE :
Store at 4° C
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
PubChem CID :
44134730Index Merck :
12: 4398
SMILES :
CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC.OS(=O)(=O)O
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SAMPLE Certificate of Analysis (COA)
Gentamicin sulfate, 100X solution | CAS 1405-41-0 SAMPLE Certificate of AnalysisCERTIFICAT D'ANALYSE
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SAMPLE Certificate of Analysis (COA)
Catalog Number:sc-361877
Lot Number:SAMPLE
Product Name:Gentamicin Sulfate, 100X Solution
Molecular Formula:C21H43N5O7•H2SO4
Molecular Weight:575.67
Test | Specification | Results |
---|---|---|
Appearance | Clear to light yellow solution | |
Concentration | 10 mg/ml in DI water | |
pH | 4.9 | |
Specific Rotation | +118° | |
Loss on Drying | 7.5% | |
Potency | 640 um/mg | |
Potency (Dry Basis) | 635 mcg/mg | |
Gentamycin C(1) | 30.1% | |
Gentamycin C(1a) | 30.8% | |
Gentamycin C(2a) + C(2) | 39.1% | |
Methanol | > 1.0% | |
Sulfated Ash | 0.2% | |
Water Content | 9.8% |
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