Reagents and instruments for immunology, cell biology and molecular biology.

Iroxanadine [203805-20-3]

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Cat# T27627-5mg

Size : 5mg

Brand : TargetMol

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Iroxanadine

(Synonyms: BRX-235, BRX235, BRX-005, BRX005, BRX 235, BRX 005) Copy Product Info

Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pulmonary artery preparations precontracted with phenylephrine.13480-84-5

Cas No. 203805-20-3

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.04%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Information

Bioactivity

Description	Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pulmonary artery preparations precontracted with phenylephrine.13480-84-5
In vivo	Iroxanadine improves the survival of vascular endothelial cells (ECs) following ischemia/reperfusion stress. ECs cultured from human umbilical veins were exposed to hypoxia/reoxygenation to mimic ischemia/reperfusion. Caspase activation and apoptosis were monitored in the reoxygenated cells. The addition of Iroxanadine (0.1-1 μM) to the culture medium prior to hypoxia or at the start of reoxygenation significantly reduced the caspase-dependent apoptosis.[1]
Synonyms	BRX-235, BRX235, BRX-005, BRX005, BRX 235, BRX 005

Chemical Properties

Molecular Weight	260.33
Formula	C₁₄H₂₀N₄O
Cas No.	203805-20-3
Smiles	C(C1NC(=NOC1)C=2C=CC=NC2)N3CCCCC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (172.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8413 mL	19.2064 mL	38.4128 mL	192.0639 mL
5 mM	0.7683 mL	3.8413 mL	7.6826 mL	38.4128 mL
10 mM	0.3841 mL	1.9206 mL	3.8413 mL	19.2064 mL
20 mM	0.1921 mL	0.9603 mL	1.9206 mL	9.6032 mL
50 mM	0.0768 mL	0.3841 mL	0.7683 mL	3.8413 mL
100 mM	0.0384 mL	0.1921 mL	0.3841 mL	1.9206 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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