The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71)
Synonyms
DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data
Protein Categories
CD Markers, Intracellular Proteins, Membrane Proteins
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