Mouse MUC4 (Mucin 4) Sandwich ELISA Kit Ready-To-Use E0017174)

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Muc4
Gene ID:	140474
Uniprot ID:	MUC4_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in trachea, duodenum and intestine. Lower expression in stomach, salivary glands, liver, gallbladder, and kidney.
Post Translational Modifications	Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. Mucin-4 alpha chain: Highly O-glycosylated. Mucin-4 beta chain: Predominantly N-glycosylated.
Function	Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
Protein Name	Mucin-4 Muc-4 Ascites Sialoglycoprotein Asgp Pancreatic Adenocarcinoma Mucin Testis Mucin Cleaved Into - Mucin-4 Alpha Chain Ascites Sialoglycoprotein 1 Asgp-1 - Mucin-4 Beta Chain Ascites Sialoglycoprotein 2 Asgp-2
Database Links	Reactome: R-MMU-913709 Reactome: -MMU-977068
Cellular Localisation	Mucin-4 Beta Chain: Cell Membrane Single-Pass Membrane Protein Isoforms Lacking The Cys-Rich Region Egf-Like Domains And Transmembrane Region Are Secreted Secretion Occurs By Splicing Or Proteolytic Processing Mucin-4 Alpha Chain: Cell Membrane Secreted Forms A Complex With Mucin-4 Beta Chain At The Cell Membrane
Alternative ELISA Names	Mucin-4 ELISA kit Muc-4 ELISA kit Ascites Sialoglycoprotein ELISA kit Asgp ELISA kit Pancreatic Adenocarcinoma Mucin ELISA kit Testis Mucin Cleaved Into - Mucin-4 Alpha Chain ELISA kit Ascites Sialoglycoprotein 1 ELISA kit Asgp-1 - Mucin-4 Beta Chain ELISA kit Ascites Sialoglycoprotein 2 ELISA kit Asgp-2 ELISA kit Muc4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance