Picloram

Biological Activity

Picloram (4-Amino-3,5,6-trichloropyridine-2-carboxylic acid) is a chlorinated systemic herbicide widely used for woody plant and broad-leaved weed control. Picloram has been used as a supplement in the growth media for culturing embryos. Picloram induces direct somatic embryogenesis of Lilium longiflorum var. Ceb-dazzel.

Chemical Information

Molecular Weight	241.46
Formula	C6H3Cl3N2O2
CAS Number	1918-02-1
Solubility (25°C)	Soluble in acetone
Storage	2-8°C, dry, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Luz Irina A Calderon Villalobos, et al. Nat Chem Biol. A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin