Pitavastatin Calcium

Biological Activity

Pivastatin calcium (Livalo) is a new member of the statin group. Like other statins, it is an inhibitor of hmG-COA reductase, an enzyme that catalyzes the first step in cholesterol synthesis. Most statins are metabolized in part by one or more liver cytochrome P450 enzymes, leading to an increased likelihood of complex interactions and problems with certain foods, such as grapefruit juice. Pivastatin appears to be a substrate for CYP2C9, rather than CYP3A4(a common source of interactions with other statins).

Product Citations

• 

  Pak J Pharm Sci. 2016 May;29(3 Suppl):1043-51.

  Chromatographic resolution of drug analogues: 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins)
  Pitavastatin Calcium purchased from AbMole

Customer Product Validations & Biological Datas

	Source	Pak J Pharm Sci (2016). Figure 1. Pitavastatin calcium (Abmole Bioscience)
	Method	HPLC chromatogram
	Cell Lines
	Concentrations	80μg/ml
	Incubation Time
	Results	The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts.

Chemical Information

Molecular Weight	880.98
Formula	C50H46CaF2N2O8
CAS Number	147526-32-7
Solubility (25°C)	DMSO 49 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Junying Wang, et al. Simultaneous Determination of Telmisartan and Pitavastatin Calcium in Intestinal Perfusate by HPLC: Application to Intestinal Absorption Interaction Study

[2] Paul Chan, et al. An evaluation of pitavastatin for the treatment of hypercholesterolemia

[3] Laurie L Yee, et al. Pitavastatin calcium: clinical review of a new antihyperlipidemic medication

[4] Keijiro Saku, et al. Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): the PATROL trial

[5] R Y A Mukhtar, et al. Pitavastatin