Plasma Selectin (P-selectin) is a cell adhesion molecule (CAM) found in granules in endothelial cells (cells lining blood vessels) and activated platelets. P-Selectin is expressed on activated endothelium and platelets where it can bind monocytes, neutrophils, stimulated T cells, and platelets.¹ P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface. Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin.² P-selectin-mediated adhesion is an important factor in the development of early atherosclerotic lesions.¹

Fc Fusion Protein

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Trp42

Lyophilized

The predicted molecular weight of Recombinant Mouse P-Selectin is Mr 99.1 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 190-200 kDa.

99.1

This recombinant protein was 0.2 µm filtered and lyophilized from 1X PBS with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Wagner, DD. et al. (1997) J Clin Invest. 99: 1037
2. Cleator, JH. et al. (2006) Blood 107: 2736