Size : 50mg
Synonyms:
| Description | SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1]. |
| In vitro | SCD1-IN-1 (compound I, 6 days) effectively inhibits SCD1 enzyme activity in intact human cells, with an IC50 of 6.8 nM [1]. |
| In vivo | SCD1-IN-1 (compound I, 1.5% w/v, 25 μL), applied to the ventral surfaces of both ears of the hamster ear model [1] at a dosage of 1.5% in a vehicle of propylene glycol/transcutanol/ethanol (20/20/60, w/v, 25 μL), twice daily for two weeks, significantly reduces cholesterol ester (CE) and wax ester (WE) production by 62% and 82%, respectively, indicating its effectiveness in modulating sebum production and sebaceous gland size in this model. |
| Molecular Weight | 395.37 |
| Formula | C20H20F3NO4 |
| Cas No. | 1111078-63-7 |
| Smiles | O(C1=C(C(F)(F)F)C=CC=C1)[C@@H]2CN(C(COC3=CC=C(CO)C=C3)=O)CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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