Reagents and instruments for immunology, cell biology and molecular biology.
 
> VHL (Elongin Binding Protein, G7 Protein, HRCA 1, HRCA1, Protein G7, pVHL, RCA 1, RCA1, VHL 1, VHL, VHL, VHL1, VHLH, Von Hippel Lindau Disease Tumor Suppressor, von Hippel Lindau Syndrome, von Hippel Lindau Tumor Suppressor, Von Hippel Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase, Von Hippel-Lindau Disease Tumor Suppressor)

VHL (Elongin Binding Protein, G7 Protein, HRCA 1, HRCA1, Protein G7, pVHL, RCA 1, RCA1, VHL 1, VHL, VHL, VHL1, VHLH, Von Hippel Lindau Disease Tumor Suppressor, von Hippel Lindau Syndrome, von Hippel Lindau Tumor Suppressor, Von Hippel Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase, Von Hippel-Lindau Disease Tumor Suppressor)

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Cat# 226659-50ul

Size : 50ul

Brand : US Biological

Contact local distributor :


Phone : +1 850 650 7790

Host
rabbit

Isotype
IgG

Grade
Affinity Purified

Applications
IF IHC WB

Shipping Temp
Blue Ice

Storage Temp
-20°C

Elongin Binding Protein, G7 Protein, HRCA 1, HRCA1, Protein G7, pVHL, RCA 1, RCA1, VHL 1, VHL, VHL, VHL1, VHLH, Von Hippel Lindau Disease Tumor Suppressor, von Hippel Lindau Syndrome, von Hippel Lindau Tumor Suppressor, Von Hippel Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase, Von Hippel-Lindau Disease Tumor Suppressor,
Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.
Applications:
Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry. Other applications not tested.
Recommended Dilutions:
Western Blot: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Immunofluorescence: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Product Type
Pab
Isotype
IgG
Host
rabbit
Source
human
Concentration
~1mg/ml
Form
Supplied as a liquid PBS, pH 7.2. 0.02% sodium azide, 50% glycerol.
Purity
Purified by immunoaffinity chromatography.
Immunogen
Full-length recombinant protein corresponding to human VHL.
Specificity
Recognizes endogenous levels of human VHL. Species Crossreactivity
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.