XPC FISH Probe

Fluorescent In Situ Hybridization (Cell)

Entrez GeneID

Gene Name

XPC

Gene Alias

XP3, XPCC

Gene Description

xeroderma pigmentosum, complementation group C

Omim ID

Gene Ontology

Gene Summary

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Other Designations

xeroderma pigmentosum group C protein