Anti-HTR1B antibody (180-260 Internal)

Cat# NB-22-5756-200ul

Size : 200µg

Brand : Neo Biotech

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Phone : +1 850 650 7790

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-1B Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HepG2 cells using 5-HT-1B antibody.
  • Immunofluorescence analysis of HeLa cells, using 5-HT-1B Antibody. The picture on the right is blocked with the synthesized peptide.

General Info

Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-5-hydroxytryptamine receptor 1B (201-250 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Information

Gene Symbol: HTR1B
Gene ID: 3351
Uniprot ID: 5HT1B_HUMAN
Immunogen Region: 201-250 aa
Specificity: SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human 5-HT-1B at the amino acid range 201-250

Description

Post Translational Modifications Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Protein Name 5-Hydroxytryptamine Receptor 1b
5-Ht-1b
5-Ht1b
S12
Serotonin 1d Beta Receptor
5-Ht-1d-Beta
Serotonin Receptor 1b
Database Links Reactome: R-HSA-390666
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-5-Hydroxytryptamine Receptor 1b antibody
Anti-5-Ht-1b antibody
Anti-5-Ht1b antibody
Anti-S12 antibody
Anti-Serotonin 1d Beta Receptor antibody
Anti-5-Ht-1d-Beta antibody
Anti-Serotonin Receptor 1b antibody
Anti-HTR1B antibody
Anti-HTR1DB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance