Inflammasome

Inflammasome


The inflammasome is a multiprotein oligomer responsible for the activation of inflammatory responses. The inflammasome promotes the maturation and secretion of pro-inflammatory cytokines Interleukin 1β (IL-1β) and Interleukin 18 (IL-18). The secretion of these cytokines results in pyroptosis, a form of programmed pro-inflammatory cell death distinct from apoptosis. In the case of dysregulation of the inflammasome, an assortment of major diseases may arise. It is expressed in myeloid cells and is a component of the innate immune system. The inflammasome complex can consist of caspase 1, PYCARD, NALP and sometimes caspase 5 (also known as caspase 11 or ICH-3). NLRs (nucleotide-binding oligomerization domain and leucine-rich repeat-containing receptors) and ALRs (AIM2-like receptors) can also form an inflammasome. The exact composition of an inflammasome depends on the activator which initiates inflammasome assembly, e.g. dsRNA will trigger one inflammasome composition whereas asbestos will assemble a different variant. Because the pro-inflammatory pathway does not need Toll-like receptors (TLRs), inflammasomes with AIM2 can detect cytoplasmic DNA, a danger signal, that may be threatening and strengthen their innate response.



Inflammasome - Therapeutic implications
Inflammasomes are assembled from a model recognition receptor, Asc adapter protein and caspase-1 to treat interleukin-1β (IL-1β) and IL-18 in response to microbial components or associated signals to the damage.

Microtubules et inflammasome complex assembly
Inflammasomes are assembled from a pattern-recognition receptor, the adapter protein Asc and caspase-1 to process interleukin-1b (IL-1b) and IL-18 in response to microbial components or damage-associated signals.

Inflammasome "Priming" activators
Priming of the NLRP3 Inflammasome

Inflammasome Signlaing - related proteins and antibodies
Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of caspase-1 and interleukine-1β (IL-1β) from cells of the innate immune system.

Standard inflammasomes signaling antibodies
Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of caspase-1 and interleukine-1β (IL-1β) from cells of the innate immune system.

Specific caspase-1 Detection
Caspase-1 plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D.

Inflammasome signaling
From innate to adaptive immunity