SARS-CoV-2 (2019-nCoV) Antigens, Antibodies & ELISA kits

SARS-CoV-2 (2019-nCoV) Antigens, Antibodies & ELISA kits

A complete range of products from Sino Biological

The newly identified coronavirus, SARS-CoV-2 (2019-nCoV), has led to pneumonia (COVID-19) that sickened over 240,000 people worldwide. SARS-CoV-2 belongs to the Betacoronavirus Genus, which also includes SARS CoV (2003) and MERS CoV (2012). Same as all other coronaviruses, the genome of SARS-CoV-2 (2019-nCoV) encodes the spike protein, the envelope protein, the membrane protein, and the nucleocapsid protein.

The spike protein (S-protein) mediates receptor binding and membrane fusion. Spike protein contains two subunits, S1 and S2. S1 contains a receptor binding domain (RBD), which is responsible for recognizing and binding with the cell surface receptor. S2 subunit is the "stem" of the structure, which contains other basic elements needed for the membrane fusion. The spike protein is the common target for neutralizing antibodies and vaccines. It's been reported that SARS-CoV-2 (2019-nCoV) (ref.) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. Indeed, the recombinant Spike protein can bind with recombinant ACE2 protein.

The Nucleocapsid Protein (N-protein) is the most abundant protein in coronavirus. The N-protein is a highly immunogenic phosphoprotein, and it is normally very conserved. The N protein of coronavirus is often used as a marker in diagnostic assays.


SARS-CoV-2 antigens




N-protein
His - Insect cell expressed





mFc - Human cell expressed
S-RBD
His - Insect cell expressed

Fc - Human cell expressed
Bind with ACE2
His - Human cell expressed

rFc - Human cell expressed




S-Protein
His - ECD, Insect cell expressed
Bind with ACE2






 
His- Human cell expressed
S1
mFc - Human cell expressed
Bind with ACE2
Fc - Human cell expressed
 
His - Insect cell expressed

 
 
 
S2 ECD
His - Insect cell expressed
 
mFc - Human cell expressed
 
 
 

 
 
 
Plpro
His - E.coli cell expressed
 
 
 

SARS-CoV-2 Antibodies




N-Antibody
Rabbit MAb / WB,IHC







S-Antibody
Rabbit MAb / ELISA,IF





SARS-CoV-2 ELISA kits




N-Protein
 







S-Protein