embalaje : 10mg
Synonyms: Lumiprobe Cy 5.5 amine, Cy 5.5 amine
| Description | α-MSH acetate is an endogenous neuromodulatory peptide derived from POMC and an agonist of MC4R (melanocortin receptor 4). It inhibits food intake, fever, and inflammation, exhibiting multiple biological activities. |
| In vitro | α-MSH acetate regulates inflammation in the central nervous system (CNS) by directly acting on melanocortin receptors within glial cells; at the same time, α-MSH can modulate the activation process of NFκB and inhibit its translocation into the cell nucleus [1]. |
| In vivo | Intraperitoneal injection of α-MSH acetate (50 μg/0.2 ml saline) effectively modulates the inflammatory response in IL-10-deficient mice. [1] |
| Synonyms | Lumiprobe Cy 5.5 amine, Cy 5.5 amine |
| Sequence | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂ |
| Sequence Short | SYSMEHFRWGKPV |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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