Anti-LGALS3 antibody (1-100) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	LGALS3
Gene ID:	3958
Uniprot ID:	LEG3_HUMAN
Immunogen Region:	1-100
Immunogen:	N-epitope synthetic peptide taken within amino acid sequences 1-100 on human Galectin 3 protein.

Tissue Specificity	A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Function	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Protein Name	Galectin-3 Gal-3 35 Kda Lectin Carbohydrate-Binding Protein 35 Cbp 35 Galactose-Specific Lectin 3 Galactoside-Binding Protein Galbp Ige-Binding Protein L-31 Laminin-Binding Protein Lectin L-29 Mac-2 Antigen
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-879415 Reactome: R-HSA-8939246 Reactome: R-HSA-8941333
Cellular Localisation	Cytoplasm Nucleus Secreted Secreted By A Non-Classical Secretory Pathway And Associates With The Cell Surface Can Be Secreted The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Antibody Names	Anti-Galectin-3 antibody Anti-Gal-3 antibody Anti-35 Kda Lectin antibody Anti-Carbohydrate-Binding Protein 35 antibody Anti-Cbp 35 antibody Anti-Galactose-Specific Lectin 3 antibody Anti-Galactoside-Binding Protein antibody Anti-Galbp antibody Anti-Ige-Binding Protein antibody Anti-L-31 antibody Anti-Laminin-Binding Protein antibody Anti-Lectin L-29 antibody Anti-Mac-2 Antigen antibody Anti-LGALS3 antibody Anti-MAC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance