embalaje : 5mg
Synonyms:
| Description | Aristolochic acid III is a naturally occurring nitrophenanthrene carboxylic acid and a structural isomer of aristolochic acid I, frequently found as a minor contaminant in Aristolochia herbal extracts. It acts as a potent DNA-damaging agent, forming both 2′-deoxyguanosine and 2′-deoxyadenosine adducts, with dose-adjusted adduct levels 30 to 80 times higher than those of aristolochic acid I in the kidney and urinary bladder. This compound exhibits strong organotropism for the urinary system, where its DNA adduct formation is uniquely elevated compared to other related genotoxicants. Aristolochic acid III is primarily used in mechanistic toxicology and DNA adductomics research to investigate organ-specific genotoxicity and the molecular origins of urinary tract carcinogenesis. |
| Molecular Weight | 341.27 |
| Formula | C17H11NO7 |
| Cas No. | 7267-92-7 |
| Smiles | O=C(C1=CC2=C(C3=C1C([N+]([O-])=O)=CC4=CC=C(OC)C=C34)OCO2)O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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