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> beta-Eudesmol [473-15-4]

beta-Eudesmol [473-15-4]

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Referencia orb1222225-25mg

embalaje : 25mg

Marca : Biorbyt


beta-Eudesmol

SKU: orb1222225

Description

β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.

Images & Validation

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beta-Eudesmol

Key Properties

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CAS Number473-15-4
MW222.37
Purity>98% (HPLC)
FormulaC15H26O
SMILESCC(C)(O)[C@@H]1CC[C@@]2(C)CCCC(=C)[C@@H]2C1
TargetnAChR| TRPA1| TRPV3| TRPM8
SolubilityIn Vitro: DMSO : 100 mg/mL (449.70 mM)

Bioactivity

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In Vivo
Animal model: Male KM mice model. Dosage: 1.25 mg/kg, 2.5 mg/kg, 5 mg/kg. Administration: Intraperitoneal injection (i.p.); Once daily for 7 days. Result: Inhibited the growth of H22 tumor cells with inhibition rates of 39.9% (2.5 mg/kg) and 49.3%(5 mg/kg), respectively. Inhibited the growth of S108 tumor cells with inhibition rates of 22.4% (2.5 mg/kg) and 42.2%(5 mg/kg), respectively. Significantly decreased vascular index with inhibition rates of 34.4% (2.5 mg/kg) and 44.3% (5 mg/kg). Animal model: Male C57BL/6 mice model. Dosage: 50 mg/kg, 100 mg/kg. Administration: Intraperitoneal injection (i.p.); Single dose. 2 h before the cecal ligation and puncture (CLP) operation. Result: Increased the expression of TNF-α, IL-1β and IL-6 in a dose-dependent manner. Increased the levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO). Inhibit the phosphorylation of p65.
In Vitro
Western blot analysis. Cell line: HL-60. Concentration: 40 μM, 80 μM. Incubation time: 4 h. Result: Increased the expression of caspase-3 protein at 80 μM. Cell Viability Assay Cell line: HL-60. Concentration: 10 μM, 20 μM, 40 μM, 60 μM, 80 μM, 120 μM. Incubation time: 4 h. Result: Didn’t affect cell activity at a dose of 40 μM, but decreased cell activity at a dose of 80 μM, and cell viability decreased by 51.6%. Apoptosis Analysis Cell line: HL-60. Concentration: 40 μM, 80 μM. Incubation time: 4 h. Result: Had no effect on apoptosis at the dose of 40 μM, but induced apoptosis at the dose of 80 μM, and the apoptosis rate was 31.7%.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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  • beta-Eudesmol

    beta-Eudesmol [orb1303641]

    95.62% (May vary between batches)

    473-15-4

    222.37

    C15H26O

    10 mg, 5 mg, 1 mg, 1 ml x 10 mM (in DMSO), 25 mg
  • Eudesmol

    Eudesmol [orb1685090]

    98.00% (May vary between batches)

    51317-08-9

    224.39

    C15H28O

    2 mg
  • 1beta-Hydroxy-beta-eudesmol

    1beta-Hydroxy-beta-eudesmol [orb1683854]

    83217-89-4

    238.37

    C15H26O2

    5 mg

Quick Database Links

Gene Symbol
nAChR| TRPA1| TRPV3| TRPM8

Protocol Information