CCR5 Antibody
Referencia OAEE00700
embalaje : 100tests(T100)
Marca : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for CCR5 Antibody |
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| Predicted Species Reactivity | Human |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | T21/8 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | APC |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | CCR5 peptide (Met1-Lys22) KLH conjugate |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 10 ul / test |
| Specificity | The mouse monoclonal antibody T21/8 recognizes the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells. |
| Formulation | APC |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Mascalchi P, Lamort AS, Salomé L, Dumas F: Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes. Biochem Biophys Res Commun. 2012 Jan 6;417(1):409-13 Monde K, Maeda Y, Tanaka Y, Harada S, Yusa K: Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5. J Biol Chem. 2007 Dec 21;282(51):36923-32. Hüttenrauch F, Pollok-Kopp B, Oppermann M: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. J Biol Chem. 2005 Nov 11;280(45):37503-15. Pollok-Kopp B, Schwarze K, Baradari VK, Oppermann M: Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem. 2003 Jan 24;278(4):2190-8. |
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| Gene Symbol | CCR5 |
| Gene Full Name | C-C motif chemokine receptor 5 |
| Alias Symbols | C-C chemokine receptor type 5, C-C motif chemokine receptor 5 A159A, CC-CKR-5, CCCKR5, CCR-5, CD195, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemokine recptor CCR5 Delta32, chemr13, CKR-5, CKR5, CMKBR5, HIV-1 fusion coreceptor, IDDM22, mutant C-C motif chemokine receptor. |
| NCBI Gene Id | 1234 |
| Protein Name | C-C chemokine receptor type 5 |
| Description of Target | Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. |
| Uniprot ID | P51681 |
| Protein Accession # | NP_000570.1; NP_001093638.1 |
| Nucleotide Accession # | NM_000579.3; NM_001100168.1 |
