Cholesterol
Referencia M2516-500mg
embalaje : 500mg
Marca : AbMole Bioscience
Quality Control & Documentation
Biological Activity
Cholesterol is a major sterol in mammals, accounting for 20-25% of the structural components of the plasma membrane, and plays an important role in characterizing membrane fluidity and permeability, as well as the function of transporter and signaling proteins. In addition, Cholesterol is an endogenous estrogen-related receptor alpha (ERRα) agonist.
Chemical Information
Molecular Weight | 386.65 |
Formula | C27H46O |
CAS Number | 57-88-5 |
Solubility (25°C) | Ethanol 8 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] David S Schade, et al. Cholesterol Review: A Metabolically Important Molecule
[2] Jie Luo, et al. Mechanisms and regulation of cholesterol homeostasis
[3] Vinay Narwal, et al. Cholesterol biosensors: A review
[4] Victor A Cortes, et al. Physiological and pathological implications of cholesterol
[5] H J Weis. Cholesterol metabolism