embalaje : 50mg
Synonyms: (±)-β-Citronelloll-d3, (±)-Citronelloll-d3
| Description | Citronellol-d3 ((±)-Citronelloll-d3) is the deuterium-labeled form of Citronellol. Citronellol ((±)-Citronellol) acts as an orally effective apoptosis inducer. It can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the Parkinson's disease model of SH-SY5Y cells induced by 6-OHDA through the regulation of ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Additionally, Citronellol induces necroptosis in human lung cancer cells via the TNF-α pathway and reactive oxygen species (ROS) accumulation. It modulates the autophagy pathway by reducing LC-3 and p62 levels, inhibiting oxidative stress and neuroinflammation, thus offering neuroprotective effects in rat models of Parkinson's disease. Furthermore, Citronellol exhibits antifungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis. |
| Synonyms | (±)-β-Citronelloll-d3, (±)-Citronelloll-d3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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