COL4A2 Antibody
Referencia OABB00475
embalaje : 100ug/vial
Marca : Aviva Systems Biology
Phospho-IRF3 (S386) Recombinant Antibody [4H10] (OACA12158)
| Datasheets/Manuals | Printable datasheet for IRF3 Recombinant Antibody [4H10] (OACA12158) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Recombinant Monoclonal |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay, Western blot |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | A synthesized peptide derived from human Phospho-IRF3 (S386) |
| Purification | Affinity Purified |
| Gene Symbol | IRF3 |
|---|---|
| Gene Full Name | interferon regulatory factor 3 |
| Alias Symbols | IIAE7;interferon regulatory factor 3. |
| NCBI Gene Id | 3661 |
| Protein Name | Interferon regulatory factor 3 |
| Description of Target | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
| Uniprot ID | Q14653 |