Dobutamine (hydrochloride) [49745-95-1]
Referencia HY-15746-100mg
embalaje : 100mg
Marca : MedChemExpress
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
Para uso exclusivo en investigación. No vendemos a pacientes.
Dobutamine hydrochloride Estructura química
No. CAS : 49745-95-1
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Other Forms of Dobutamine hydrochloride:
- Dobutamine Obtener un presupuesto
- Dobutamine tartrate Obtener un presupuesto
- (rac)-Dobutamine-d4 hydrochloride Obtener un presupuesto
- (rac)-Dobutamine-d6 hydrochloride Obtener un presupuesto
Descripciòn |
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4]. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target |
|
||||||||||||
In Vivo |
Dobutamine hydrochloride has a rapid onset of action and a short half-life [2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||
Ensayo clínico |
|
||||||||||||
Peso molecular |
337.84 |
||||||||||||
Fòrmula |
C18H24ClNO3 |
||||||||||||
No. CAS |
49745-95-1 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
White to gray |
||||||||||||
SMILES |
OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.12Cl |
||||||||||||
Envío | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Almacenamiento |
4°C, sealed storage, away from moisture *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture) |
||||||||||||
Solvente y solubilidad |
In Vitro:
DMSO : ≥ 33 mg/mL (97.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 20 mg/mL (59.20 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
|
||||||||||||
Pureza y Documentación |
Purity: 99.91% |
||||||||||||
Referencias |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
H2O / DMSO | 1 mM | 2.9600 mL | 14.7999 mL | 29.5998 mL | 73.9995 mL |
5 mM | 0.5920 mL | 2.9600 mL | 5.9200 mL | 14.7999 mL | |
10 mM | 0.2960 mL | 1.4800 mL | 2.9600 mL | 7.4000 mL | |
15 mM | 0.1973 mL | 0.9867 mL | 1.9733 mL | 4.9333 mL | |
20 mM | 0.1480 mL | 0.7400 mL | 1.4800 mL | 3.7000 mL | |
25 mM | 0.1184 mL | 0.5920 mL | 1.1840 mL | 2.9600 mL | |
30 mM | 0.0987 mL | 0.4933 mL | 0.9867 mL | 2.4667 mL | |
40 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8500 mL | |
50 mM | 0.0592 mL | 0.2960 mL | 0.5920 mL | 1.4800 mL | |
DMSO | 60 mM | 0.0493 mL | 0.2467 mL | 0.4933 mL | 1.2333 mL |
80 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9250 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.