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Dodecylphosphocholine [29557-51-5]

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Referencia NB-64-09563-50mg

embalaje : 50mg

Marca : Neo Biotech

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Dodecylphosphocholine

(Synonyms: n-C12PC, nC12PC, n C12PC, Foscholine-12, DPC, DDPPC) Copy Product Info

Synonyms: n-C12PC, nC12PC, n C12PC, Foscholine-12, DPC, DDPPC

Catalog No. T19729 Copy Product Info

Purity: 99.73%

Dodecylphosphocholine (DPC) is a substrate-type inhibitor of pancreas phospholipase A2. Dodecylphosphocholine is a detergent.

Cas No. 29557-51-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.73%

Appearance:Solid

Color:White

Product Introduction

Dodecylphosphocholine AI Summary

Dodecylphosphocholine shows antifungal activity against Cryptococcus neoformans ATCC 90112 with a MIC of 175,000 nM and against Candida albicans ATCC 10231 with a MIC of 350,000 nM. It demonstrates no haemolytic activity against human erythrocytes at concentrations ranging from 3.5 µM to 175 µM. Additionally, Dodecylphosphocholine induces membrane perturbation in DC22:1PC LUV bilayers by promoting the transition of gramicidin from monomer to dimer form, as evaluated through a fluorescence quenching assay, with a recorded deltaG value of -0.5 kcal/mol..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dodecylphosphocholine (DPC) is a substrate-type inhibitor of pancreas phospholipase A2. Dodecylphosphocholine is a detergent.
Synonyms	n-C12PC, nC12PC, n C12PC, Foscholine-12, DPC, DDPPC

Chemical Properties

Molecular Weight	351.462
Formula	C₁₇H₃₈NO₄P
Cas No.	29557-51-5
Smiles	O=P([O-])(OCCCCCCCCCCCC)OCC[N+](C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (142.26 mM), Sonication is recommended.

H2O: 50.00 mg/mL (142.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (5.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8453 mL	14.2263 mL	28.4526 mL	142.2629 mL
5 mM	0.5691 mL	2.8453 mL	5.6905 mL	28.4526 mL
10 mM	0.2845 mL	1.4226 mL	2.8453 mL	14.2263 mL
20 mM	0.1423 mL	0.7113 mL	1.4226 mL	7.1131 mL
50 mM	0.0569 mL	0.2845 mL	0.5691 mL	2.8453 mL
100 mM	0.0285 mL	0.1423 mL	0.2845 mL	1.4226 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

proteinpancreas phospholipase A2membraneInhibitorinhibitDodecylphosphocholinedetergent

Related Tags: Dodecylphosphocholine chemical structure | Dodecylphosphocholine formula | Dodecylphosphocholine molecular weight